生物活性

• 描述20-Hydroxyecdystone (20E) is an ecdysteroid hormone which controls molting and reproduction in arthropods. 20E also produces a variety of effects in vertebrates, including enhancing protein synthesis and skeletal muscle regeneration. 20E treatment tended to attenuate disuse muscle atrophy and reduced ubiquitination only in soleus muscle^[3]. The progressive increase in systolic blood pressure with age in SHR (spontaneously hypertensive rats) rats was significantly lower in animals treated with either 5 or 10mg/kg body weight of 20-HE (20-hydroxyecdysone). Echocardiography after six weeks of treatment demonstrated that the left ventricular chamber of SHR rats treated with 20-HE was smaller than that of SHR controls, while contractility was not affected by 20-HE. Histological images also demonstrated a decrease in cardiomyocyte cross-sectional area in 20-HE treated groups. Interestingly, treatment with 20-HE caused a shift in cardiac myosin heavy chain towards more β-isoforms. SHR rats treated with 20-HE also exhibited a decrease in seminal vesicular weight and an increase in testicular weight, especially at a dose of 10mg/kg body weight. 20-HE has a beneficial effect on reducing blood pressure and consequently preventing dilated cardiac hypertrophy in SHR rats^[4]. Exposure of daphnids to elevated concentrations of 20-hydroxyecdysone caused premature and incomplete ecdysis resulting in death. Tributyltin exaggerated this effect of exogenous 20-hydroxyecdysone. Further, exposure of daphnids to tributyltin enhanced the inductive effects of 20-hydroxyecdysone on expression of the 20-hydroxyecdysone-inducible gene HR3^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03452488	Sarcopenia	Phase 2	Recruiting	December 2019	United States, Florida ... more >> Institut On Aging Not yet recruiting Gainesville, Florida, United States, 32611 Contact: Marco Pahor, Pr          Contact: Annie Allen          United States, Massachusetts Jean Mayer USDA Human Nutrition research Center on Aging Tufts University Recruiting Boston, Massachusetts, United States, 02111 Contact: Roger A Fielding, Pr          Contact: Sarah White          United States, North Carolina Bowman Gray Center for Medical Education-of- Wake Forest School of Medicine Recruiting Winston-Salem, North Carolina, United States, 27101 Contact: Stephan Kritchevsky, Dr          United States, Texas Medical Center Recruiting Houston, Texas, United States, 77030 Contact: Denis Villareal, Dr          Belgium Vrije Universiteit Brussel Recruiting Bruxelles, Belgium, 1090 Contact: Ivan Bautmans, Pr          Universitaire Ziekenhuizen (UZ) Leuven - Gasthuisberg - Centrum voor metabole botziekten Not yet recruiting Leuven, Belgium, 3000 Contact: Evelien Gielen, Dr          Université de Liège Recruiting Liège, Belgium, 4020 Contact: Olivier Bruyere, PhD          Contact: Médéa Locquet, Ph          France Hôpital Broca Département de Gerontologie Not yet recruiting Paris, France, 75005 Contact: Olivier Hanon, Pr          Gérontopole Toulouse Not yet recruiting Toulouse, France, 31059 Contact: Yves Rolland          Contact: Emilie Durand          Italy IRCCS University-Ospedale San Martino Not yet recruiting Genova, Italy, 16132 Contact: Samir Sukkar, Pr          University of Padova Not yet recruiting Padova, Italy, 35128 Contact: Giuseppe Sergi, Pr          Policlinico Universitario Campus Biomedico Not yet recruiting Roma, Italy, 00128 Contact: Raffaele Antonelli-Incalzi, Pr    (+39) 06.22541.653       Sapienza University of Rome Policlinico Umberto1 Not yet recruiting Roma, Italy, 00185 Contact: Maurizio Muscaritoli, Pr          Sapienza University of Rome Not yet recruiting Roma, Italy, 00185 Contact: Lorenzo Donini, Pr Collapse <<

• 参考文献

• [1] Hu J, Zhao TZ, et al. Protective effects of 20-hydroxyecdysone on CoCl(2)-induced cell injury in PC12 cells. J Cell Biochem. 2010 Dec 15;111(6):1512-21.

  [2] Kizelsztein P, Govorko D, et al. 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E433-9.

  [3] Hirunsai M, Yimlamai T, Suksamrarn A. Effect of 20-Hydroxyecdysone on Proteolytic Regulation in Skeletal Muscle Atrophy. In Vivo. 2016;30(6):869-877

  [4] Phungphong S, Kijtawornrat A, Chaiduang S, Saengsirisuwan V, Bupha-Intr T. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017;126:79-84

  [5] Wang YH, Kwon G, Li H, Leblanc GA. Tributyltin synergizes with 20-hydroxyecdysone to produce endocrine toxicity. Toxicol Sci. 2011;123(1):71-79

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